منابع مشابه
Efforts to make and apply humanized yeast.
Despite a billion years of divergent evolution, the baker's yeast Saccharomyces cerevisiae has long proven to be an invaluable model organism for studying human biology. Given its tractability and ease of genetic manipulation, along with extensive genetic conservation with humans, it is perhaps no surprise that researchers have been able to expand its utility by expressing human proteins in yea...
متن کاملThe Benefits of Humanized Yeast Models to Study Parkinson's Disease
Over the past decade, the baker's yeast Saccharomyces cerevisiae has proven to be a useful model system to investigate fundamental questions concerning the pathogenic role of human proteins in neurodegenerative diseases such as Parkinson's disease (PD). These so-called humanized yeast models for PD initially focused on α -synuclein, which plays a key role in the etiology of PD. Upon expression ...
متن کاملGlycan engineering and production of 'humanized' glycoprotein in yeast cells.
Protein therapeutics, such as antibodies and cytokines, is the largest class of new drug candidates being developed by pharmaceutical companies. Although most of these glycoproteins are produced in mammalian cells, there is concern that their large-scale production could be affected by an inadequate supply of bovine serum. There is also the risk of viral infection spreading through the use of c...
متن کاملLow-ranking female Japanese macaques make efforts for social grooming
Grooming is essential to build social relationships in primates. Its importance is universal among animals from different ranks; however, rank-related differences in feeding patterns can lead to conflicts between feeding and grooming in low-ranking animals. Unifying the effects of dominance rank on feeding and grooming behaviors contributes to revealing the importance of grooming. Here, I teste...
متن کاملA Simulation-Optimization Model For Capacity Coordination In Make To Stock/Make To Order Production Environments
Capacity coordination, as the tactical level of hierarchical production planning in hybrid MTS/MTO systems, includes numerous important decisions. In this paper, two of these decisions i.e. finding the best strategy for the acceptance/rejection of incoming orders and determining orders’ due dates – are investigated. Also a simulation model is proposed to evaluate the efficiency of the presented...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2015
ISSN: 2041-2649,2041-2657
DOI: 10.1093/bfgp/elv041